The aging process involves changes in immune regulation, i.e. adaptive immunity declines whereas innate immunity becomes activated. NF‐κB signaling is the master regulator of the both immune systems. Two recent articles highlight the role of the NF‐κB system in aging and immune responses. Adler et al1 showed that the NF‐κB binding domain is the genetic regulatory motif which is most strongly associated with the aging process. Kwon et al2 studying HIV‐1 infection and subsequent immune deficiency process demonstrated that HIV‐1 Tat (...) protein binds to SIRT1 protein, a well‐known longevity factor, and inhibits the SIRT1‐mediated deacetylation of the p65 component of the NF‐κB complex. As a consequence, the transactivation efficiency of the NF‐κB factor was greatly potentiated, leading to the activation of immune system and later to the decline of adaptive immunity. These observations support the scenario where immune responses and aging process can be enforced by the potentiation of NF‐κB transactivation efficiency. Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF‐κB signaling, the major outcome of which is inflamm‐aging via proinflammatory responses. BioEssays 30:939–942, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Moral perceptualism is the view that perceptual experience is attuned to pick up on moral features in our environment, just as it is attuned to pick up on mundane features of an environment like textures, shapes, colors, pitches, and timbres. One important family of views that incorporate moral perception are those of virtue theorists and sensibility theorists. On these views, one central ability of the virtuous agent is her sensitivity to morally relevant features of situations, where this sensitivity is often (...) spoken of in perceptual terms. However, sensibility theorists have often not been careful to specify how to understand their claims about moral sensibilities as perceptual. In this paper, we distinguish between what we call Attentional Moral Perception and Contentful Moral Perception. We argue that sensibility theorists should endorse Attentional Moral Perception, because it has very powerful empirical evidence in its favor, and it can play all of the explanatory roles that the sensibility theorist needs in her theory of moral sensibilities. (shrink)

1. Sometimes perceptual experience is crystal clear, as when one inspects an object close-up in bright light with corrective lenses. But experience can be less clear. To illustrate how experiences...

When we see objects blurrily, in the periphery, or in dim light, we often experience their features unclearly. This paper argues that perceptual clarity is a dimension along which experiences vary, distinct from their distal contents. Drawing on models in perception science, the paper accounts for clarity by using the probabilistic notion of precision. The account’s first part is ecumenical: it says that experiences carry information about the precision of the representations from which each distal content of experience was selected (...) and that this precision information accounts for perceptual clarity. The account’s second part entails that experiences carry the relevant precision information in the manner in which their distal contents are represented. The precision account of clarity is shown to conform to common intuitions about experiences’ contents and accuracy conditions. And it is used to illustrate how experiences could assign probability distributions over distal possibilities, even while experiences’ contents are non-probabilistic. (shrink)

Since the 1990’s, the debate concerning the ethical, legal and societal aspects of ‘neuro-enhancement’ has evolved into a massive discourse, both in the public realm and in the academic arena. This ethical debate, however, tends to repeat the same sets of arguments over and over again. Normative disagreements between transhumanists and bioconservatives on invasive or radical brain stimulators, and uncertainties regarding the use and effectivity of nootropic pharmaceuticals dominate the field. Building on the results of an extensive European project on (...) responsible research and innovation in neuro-enhancement, we observe and encourage that the debate is now entering a new and, as we will argue, more realistic and societally relevant stage. This new stage concerns those technologies that enter the market as ostensibly harmless contrivances that consumers may use for self-care or entertainment. We use the examples and arguments of participants in NERRI debates to describe three case studies of such purportedly innocent ‘toys’. Based upon this empirical material, we argue that these ‘soft’ enhancement gadgets are situated somewhere in the boundary zone between the internal and the external, between the intimate and the intrusive, between the familiar and the unfamiliar, between the friendly and the scary and, in Foucauldian terms, between technologies of the self and technologies of control. Therefore, we describe their physiognomy with the help of a term borrowed from Jacques Lacan, namely as “extimate” technologies. (shrink)

The increasing attention to the brain in science and the media, and people’s continuing quest for a better life, have resulted in a successful self-help industry for brain enhancement. Apart from brain books, foods and games, there are several devices on the market that people can use to stimulate their brains and become happier, healthier or more successful. People can, for example, switch their brain state into relaxation or concentration with a light-and-sound machine, they can train their brainwaves to cure (...) their Attention Deficit Hyperactivity Disorder (ADHD) or solve their sleeping problems with a neurofeedback device, or they can influence the firing of their neurons with electric or magnetic stimulation to overcome their depression and anxieties. Working on your self with a brain device can be seen as a contemporary form of Michel Foucault’s ‘technologies of the self’. Foucault described how since antiquity people had used techniques such as reading manuscripts, listening to teachers, or saying prayers to ‘act on their selves’ and control their own thoughts and behaviours. Different techniques, Foucault stated, are based on different precepts and constitute different selves. I follow Foucault by stating that using a brain device for self-improvement indeed constitutes a new self. Drawing on interviews with users of brain devices and observations of the practices in brain clinics, I analyse how a new self takes shape in the use of brain devices; not a monistic (neuroscientific) self, but a ‘layered’ self of all kinds of entities that exchange and control each other continuously. (shrink)

The American Journal of Bioethics, Volume 11, Issue 11, Page 26-27, November 2011.

At a time of grave ethical failure in global security affairs, this is the first book to bring together emerging theoretical debates on ethics and ethical reasoning within security studies. In this volume, working from a diverse range of perspectives—poststructuralism, liberalism, feminism, just war, securitization, and critical theory—leading scholars in the field of security studies consider the potential for ethical visions of security, and lay the ground for a new field: "ethical security studies". These ethical ‘visions’ of security engage directly (...) with the meaning and value of security and security practice, and consider four key questions: • Who, or what, should be secured? • What are the fundamental grounds and commitments of different security ethics? • Who or what are the most legitimate agents, providers or speakers of security? • What do ethical security practices look like? What ethical principles, arguments, or procedures, will generate and guide ethical security practices? Informed by a rich understanding of the intellectual and historical experience of security, the contributors advance innovative methodological, analytical, political and ethical arguments that represent the cutting edge of the field. This book opens a new phase of collaboration and growth that promises to have great benefits for the more humane, effective and ethical practice of security politics. This book will be of much interest to students of critical security studies, ethics, philosophy, and international relations. (shrink)

This article takes its point of departure in Bracha Ettinger’s discussion on the “matrixial borderspace”: the structure of the experience of “the womb,” both from a “mother-pole” and a “fetus-pole”. Ettinger describes this borderspace as a place of differentiation-in-co-emergence, separation-in-jointness, and distance-in-proximity. The question this article poses is what kind of logic this experience is an expression of, as there seems to be a discrepancy in relation to the classical Aristotelian logic of identity. As an alternative to classical Aristotelian logic, (...) Nicholas of Cusa’s logic of the non-aliud is explored as a paradigm more in line with Ettinger’s description of pregnancy specifically and more generally, to an understanding of life as a co-poietic emergence of structures of pactivity and permeability. (shrink)

Evil strikes directly at what we care most deeply about, and attempts to control, predict and even eliminate it often generate new and unforeseen evils. Hence, it is no surprise that philosophers and theologians keep returning to the topic. The following special issue springs from the 21st conference of the European Society for Philosophy of Religion held in Uppsala, Sweden, August 2016.

This article presents an ethnographical and historical analysis of the mode of being that is constituted when people use neurofeedback for self-improvement. I analyse how human brainwaves have been associated with the psyche since their first demonstration by the psychiatrist Hans Berger, how they were connected to personality types by the cybernetician Grey Walter, and made trainable by the psychologists Joe Kamiya and Barry Sterman. I compare these cases with the reports of contemporary neurofeedback practitioners and users, and demonstrate that (...) working on the self by working on the brain constitutes a complicated relationship between the brain and the self. Moreover, I demonstrate that combinations of brains and selves, material and spiritual ideas, and biological and social explanations are not confusions due to the ignorance of neurofeedback users, but amalgamations that emerged in the work and ideas of early scientists. (shrink)

This article examines how one of the most striking differences between the central doctrines of the Catholic Church and the secular context of Swedish society, attitudes to abortion, is managed by the Swedish church hierarchy and commentators in the official newsletter of the Catholic Church of Sweden. Using Foucauldian concepts of power, the article concludes that in its marginal position, the Catholic Church in Sweden mixes the traditional pastoral and sovereign power of the church with the way pastoral power is (...) exerted in modern society, in its efforts to continue asserting its influence over the possible courses of action for pregnant women. While traditionally abortion has been a woman’s crime, in the Swedish Catholic context it becomes rather the crime of the secular society. This means also that the image of woman as being responsible for her decisions and in need of forgiveness gives way to an image of woman as a victim in need of understanding. (shrink)

A century after the World War I, studies on the politics of memory and commemoration have grown into a vast and vital academic field. This book approaches the theme "monument and memory" from architectural, literary, philosophical, and theological perspectives. Drawing on diverse sources - from Augustine to Freud, from early photographs to contemporary urban monuments - the book's contributors probe the intersections between memory and trauma, past and present, monuments and memorial practices, religious and secular, remembrance and forgetfulness. (Series: Nordic (...) Studies in Theology / Nordische Studien zur Theologie - Vol. 1) [Subject: Philosophy, Religious Studies, History]. (shrink)

In 1968, Jürgen Habermas claimed that, in an advanced technological society, the emancipatory force of knowledge can only be regained by actively recovering the ‘forgotten experience of reflection’. In this article, we argue that, in the contemporary situation, critical reflection requires a deliberative ambiance, a process of mutual learning, a consciously organised process of deliberative and distributed reflection. And this especially applies, we argue, to critical reflection concerning a specific subset of technologies which are actually oriented towards optimising human cognition. (...) In order to create a deliberative ambiance, fostering critical upstream reflection on emerging technologies, we developed the concept of a mutual learning exercise. Building on a number of case studies, we analyse what an MLE involves, both practically and conceptually, focussing on key aspects such as ambiance and expertise, the role of ‘genres of the imagination’ and the profiles of various ‘subcultures of debate’. Ideally, an MLE becomes a contemporary version of the Socratic agora, providing a stage where multiple and sometimes unexpected voices and perspectives mutually challenge each other, in order to strength-en the societal robustness and responsiveness of emerg-ing technologies. (shrink)

An estimated 15% of patients seen by neurologists have neurological symptoms, such as paralysis, tremors, dystonia, or seizures, that cannot be medically explained. For a long time, such patients were diagnosed as having conversion disorder and referred to psychiatrists, but for the last two decades or so, neurologists have started to pay more serious attention to this patient group. Instead of maintaining the commonly used label of conversion disorder – which refers to Freud’s idea that traumatic events can be converted (...) into deviant behaviour – these neurologists use the term functional neurological disorder and explain that the problems are due to abnormal central nervous system functioning. The situation that some patients with medically unexplained neurological symptoms are diagnosed with CD and treated by psychiatrists while others are diagnosed with FND and stay under the control of neurologists provides a unique case for analysing how neurological and psychological explanations affect subjectivity. In this article, I compare patient reports from English-language websites from the past 15 years to find out how minds, bodies, brains, and selves act and interact in the accounts of both patient groups. I conclude that the change in label from CD to FND has not only influenced ideas of medically unexplained disorders, but also affected ideas of the self and the body; of self-control and accountability. (shrink)

In order to study whether there exist a period of activity in the human early visual cortex that contributes exclusively to visual awareness, we applied transcranial magnetic stimulation over the early visual cortex and measured subjective visual awareness during visual forced-choice symbol or orientation discrimination tasks. TMS produced one dip in awareness 60–120 ms after stimulus onset, while forced-choice orientation discrimination was suppressed between 60 and 90 ms and symbol discrimination between 60 and 120 ms. Thus, a time window specific (...) to visual awareness was found only in the orientation condition at 120 ms. The results imply that both conscious and unconscious perception depend on activity in early visual areas. On the basis of previous estimates of neural processing speed, we suggest that the late part of the activity period most likely involve local extrastriate–striate interactions which provide the contents for visual awareness but are not themselves sufficient for awareness to arise. (shrink)

In phenomenology, theories of empathy are intimately connected with the question of how it is possible to have insight into the mind of the other person. In this article, the author wants to show why it is self-evident for us that the other person is having experiences. In order to do so, it is not enough to discuss the phenomenon of empathy with a starting point in the already constituted adult person; instead the article presents a genetic approach to human (...) development. The author thus contrasts Edith Stein’s discussion of Einfühlung (empathy), which takes its starting point in the experience of the grown-up, with Max Scheler’s discussion of Einsfühlung (feeling of oneness), where the relation between mother and infant is taken as one example. Maurice Merleau-Ponty’s discussion of the world of the infant is read as one way of developing Scheler’s theory of intersubjectivity and of Einsfühlung. This genetic approach is developed further into a phenomenological analysis of the experience of the fetus and of birth. The author argues that the analysis of the fetus highlights the distinction between knowing that another person is having experiences, and knowing the specific content of the other person’s experiences. The fetus does not experience different persons, but has a pre-subjective experience of life that includes what is later experienced as belonging to “another.” Later in life, the experience of empathy, as an experience of a specific content, can be developed from this experience. In this way empathy and Einsfühlung can be understood as complementary rather than as competing phenomena. (shrink)

Indeed. Nothing. Not the slightest. I act in a void. Paul Celan in a letter to the editor of Tagesspiegel in October 1959 1 Without doubt Martin Heidegger was the most influential and controversial...

Rien, c’est ce qu’il faut: supporter l’insupportable rien. Maurice Blanchot Subjectivity is undoubtedly a central area of philosophical investigation. In 1984 Emmanuel Levinas (1906–95) described h...

The decisive moment of human development is continually at hand. This is why those movements of revolutionary thought that declare everything preceding to be an irrelevance are correct – because at yet nothing has happened.In his Meridian speech Paul Celan pays homage to a dissident tradition, speaking of himself as one “who grew up with Peter Kropotkin’s and Gustav Landauers’ writings” .1 In his biography John Felstiner briefly mentions Celan’s affiliation, noting that the poet soon relinquished his communist sympathies but (...) stood loyal to the ethoi of socialism and anarchism . This holds true as a point of departure, but a detailed analysis of Celan’s anarchistic impulse is lacking .. (shrink)

Name is a powerful sign, and name-giving is also calling one intolanguage. Name identifies, summons and subjects. Paul Celan wasfamiliar with all these uses of name and addresses them in his poeticsand poetry. This article will discuss how poetry like Celan’s, which is heavily influenced by so many philosophical readings, could form a critique of naming,on a poetical basis towards philosophical concepts that underline problematics of name-giving in poetic text in particular.

Programmes serving international patients are increasingly common throughout the USA. These programmes aim to expand access to resources and clinical expertise not readily available in the requesting patients’ home country. However, they exist within the US healthcare system where domestic healthcare needs are unmet for many children. Focusing our analysis on US children’s hospitals that have a societal mandate to provide medical care to a defined geographic population while simultaneously offering highly specialised healthcare services for the general population, we assume (...) that, given their mandate, priority will be given to patients within their catchment area over other patients. We argue that beyond prioritising patients within their region and addressing inequities within US healthcare, US institutions should also provide care to children from countries where access to vital medical services is unavailable or deficient. In the paper, we raise and attempt to answer the following: (1) Do paediatric healthcare institutions have a duty to care for all children in need irrespective of their place of residence, including international patients? (2) If there is such a duty, how should this general duty be balanced against the special duty to serve children within a defined geographical area to which an institution is committed, when resources are strained? (3) Finally, how are institutional obligations manifest in paradigm cases involving international patients? We start with cases, evaluating clinical and contextual features as they inform the strength of ethical claim and priority for access. We then proceed to develop a general prioritisation framework based on them. (shrink)